Precision Medicinal Chemistry Services

Transforming Hits into High-Value Clinical Leads.

Explore Target Libraries Consult Our MedChem Team

ChemEngine Pharma Solutions Pvt. Ltd. – Medicinal Chemistry Compounds Division

ChemEngine Pharma provides custom medicinal chemistry services, target-focused libraries, and novel hit-to-lead reference compounds. Designed specifically for hit identification, lead optimization, and SAR (Structure-Activity Relationship) studies, our medicinal chemistry portfolio accelerates drug discovery programs across oncology, neuroscience, infectious diseases, and immunology.

Core MedChem Offerings

Target-Focused Libraries

Scaffold-focused libraries curated for kinase inhibitors, GPCR modulators, ion channels, and epigenetic targets.

PROTAC & ADC Intermediates

Advanced warheads, functionalized E3 ligase ligands (Cereblon/VHL), and cleavable/non-cleavable linkers for targeted protein degradation.

SAR Analog Arrays

Systematic analog sets optimized for steric, electronic, and lipophilic modification to refine ADMET profiles.

Reference & Controls

Benchmark active pharmaceutical ingredients (APIs) and clinical candidates synthesized for in vitro assay validation.

Interactive Target & Scaffold Navigator

Explore our curated collections by target family and physicochemical rules.

Core Scaffold / Target

Max Mol Weight (MW)

LogP Range

SMILES Search

HBD ≤ 5 HBA ≤ 10 High Brain Penetrance (CNS)

GPCR Modulator library structures will appear here based on your filter criteria.

PPI inhibition scaffolds (e.g. specialized alpha-helix mimetics) will appear here.

HDAC, Bromodomain, and Methyltransferase inhibitors will appear here.

Integrated MedChem Services

A systematic pipeline driven by our experienced Ph.D. synthetic and medicinal chemists.

1. Hit Identification

Virtual screening & scaffold hopping.

2. Hit-to-Lead

Expansion & preliminary property testing.

3. SAR Exploration

Iterative array synthesis & biological mapping.

4. Lead Opt & ADMET

Tuning ADMET profiles to generate high-value clinical candidates.

Expert Chemist Team

Managed by senior Ph.D. synthetic and medicinal chemists.

Strict IP Protection

Rapid turn-around times with highly secure data handling protocols.

MedChem Capability & Specification Matrix

Rigorous standards across all stages of analog synthesis.

Service / Product Line	Synthesis Scale	Purity Standard	Analytical Deliverables
Focused Libraries	Milligram (1–50 mg)	≥ 90–95% (HPLC)	LC-MS, HPLC, COA, SDF files
Lead Optimization Analogs	Multi-mg to Gram	≥ 95–98% (HPLC)	¹H-NMR, LC-MS, HPLC, COA
Degrader (PROTAC) Building Blocks	Gram to Multi-gram	≥ 95% (HPLC)	1D/2D-NMR, HRMS, Purity Trace
Custom MedChem Synthesis	Tailored to scope	Up to ≥ 99%	Full characterization package (NMR, MS, Chiral HPLC)

Quality Assurance, Analytics & Packaging

We deliver assay-ready compounds formatted exactly to your screening requirements, backed by uncompromised analytical validation.

Custom Formatting Options Pre-dissolved DMSO stocks, 96-well microplates, 384-well plates, or custom solid dispensing into amber vials.
Comprehensive QC Testing Rigorous validation of purity, structural identity, and stability utilizing high-field NMR and LC-MS systems.